Dosing changes. Because SSRIs’ sexual side effects appear to be dose-related, 11 carefully reducing the dosage may reduce sexual dysfunction without compromising antidepressant efficacy. This strategy is most likely to sustain remission when you avoid dosages that have proven ineffective. If you have depression and are noticing a reduced interest in sex or problems with sexual functioning, it is important for you and your doctor to figure out if the cause of sexual dysfunction is Author: Debra Fulghum Bruce, Phd. Apr 04, · Sexual side effects, like erectile dysfunction, are common complaints of taking antidepressants. Most prescription antidepressants are part of Author: Kristeen Cherney And Kathryn Watson.
Resulting sexual dysfunction can impair quality of life and intimate relationships and discourage patients from taking antidepressants Box 12. Although most reports have focused on SSRIs, all antidepressant classes have been associated with sexual dysfunction, with prevalence likely influenced by differences in neurotransmitter modulation Table 2. A recent study reported similarly high rates with mirtazapine, but its small sample size limits antidepressant without male sexual dysfunction about side effect prevalence with this drug. Clomipramine appears to have the highest rates of sexual dysfunction—particularly anorgasmia—probably because it inhibits the serotonin transporter more than do other TCAs. MAOIs directly increase serotonergic neurotransmission, and their substantial alpha-adrenergic antagonist effects may also antidepressant without male sexual dysfunction sexual side effects. Waiting for symptoms to subside may be appropriate, as anorgasmia caused by MAOIs may remit spontaneously. Sildenafil 8 and cyproheptadine 9 may reverse MAOI sexual side effects, although serious toxicity has been reported in a patient taking cyproheptadine and an MAOI.